NCIt synonyms : Monoclonal Antibody 425; Mab 425; EMD 55900;
NCIt definition : A murine monoclonal antibody targeting the epidermal growth factor receptor (EGFR)
exhibiting anti-tumor activity. EMD 55900 antibody binds to the extracellular domain
of EGFR close to the EGF binding domain and does not induce any tyrosine kinase activity
on its own. As a result, EMD 55900 binding inhibits receptor activation by natural
ligands thereby interrupting activation of downstream signaling cascade, required
for tumor cell growth and proliferation.;