Refractory Anemia with Excess Blasts in Transformation - CISMeF
Refractory Anemia with Excess Blasts in TransformationNCIt concept
Preferred Label : Refractory Anemia with Excess Blasts in Transformation;
Obsolete resource : true;
NCIt synonyms : RAEB-T;
NCIt definition : Refractory anemia with excess blasts in transformation (RAEB-T) is characterised by
dysplastic features of the myeloid and usually erythroid progenitor cells in the bone
marrow and an increased number of myeloblasts in the peripheral blood. The peripheral
blood blast count ranges from 20% to 30%. RAEB-T used to be a subcategory of myelodysplastic
syndromes in the past. Recently, the term has been eliminated from the WHO based classification
of myelodysplastic syndromes. The reason is that the percentage of peripheral blood
blasts required for the diagnosis of acute myeloid leukemia has been reduced to 20%.
The elimination of the RAEB-T term by the WHO experts has created confusion and ongoing
arguments. Currently, according to WHO classification, the vast majority of RAEB-T
cases are best classified as acute leukemias (acute leukemias with multilineage dysplasia
following myelodysplastic syndrome). A minority of cases are part of RAEB-2.;