Preferred Label : Anthrapyrazole;
NCIt synonyms : Anthra[1,9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino
)ethyl]amino]-, acetate (salt) hydrobromide(10:5:21); Anthra[1, 9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino
)ethyl]amino]-acetate (salt) hydrobromide(10:5:21);
NCIt related terms : Anthra[1,9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino
)ethyl]amino]-, acetate (salt) hydrobromide (10:5:21); Anthra[1, 9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino
)ethyl]amino]-acetate (salt) hydrobromide (10:5:21);
NCIt definition : An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase
II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Anthrapyrazoles
may also block cell cycle division. In the presence of electron donors, some anthrapyrazole
antibiotics cause single-strand breaks in DNA via photosensitization by visible light.
These agents are less cardiotoxic than doxorubicin. (NCI04);
CAS number : 91440-30-1;
Codes from synonyms : NSC0355644;
Origin ID : C2706;
UMLS CUI : C0051960;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
