Leukoencephalopathy

Preferred Label : Leukoencephalopathy;

NCIt definition : White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.;

Alternative definition : CTCAE: A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.;

Codes from synonyms : E12712;

Details

Origin ID

C27059;

UMLS CUI

C0270612;

Currated CISMeF NLP mapping
- Leucoencephalopathy [PASCAL descriptor]
- Leukoencephalopathy [HPO term]
- Leukoencephalopathy [MedDRA Preferred Term]
- Leukoencephalopathy (disorder) [SNOMED CT concept]
- White matter disease (disorder) [SNOMED CT concept]
- leukencephalopathy [Disease (Nov.)]
- leukoencephalopathies [MeSH Descriptor]
- leukoencephalopathies [MeSH concept]
- leukoencephalopathy, nos [SNOMED Notion]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Leukoencephalopathy [MedDRA Preferred Term]
- Leukoencephalopathy [HPO term]
- Leukoencephalopathy (disorder) [SNOMED CT concept]
- White matter disease (disorder) [SNOMED CT concept]
- leukencephalopathy [Disease (Nov.)]
- leukoencephalopathies [MeSH concept]
- leukoencephalopathies [MeSH Descriptor]
- leukoencephalopathy, nos [SNOMED Notion]
disease_has_associated_gene
- EIF2B1 Gene [NCIt concept]
- EIF2B1 wt Allele [NCIt concept]
- EIF2B2 Gene [NCIt concept]
- EIF2B2 wt Allele [NCIt concept]
- EIF2B4 Gene [NCIt concept]
- EIF2B4 wt Allele [NCIt concept]
- EIF2B5 Gene [NCIt concept]
- EIF2B5 wt Allele [NCIt concept]
disease_has_primary_anatomic_site
- Brain [NCIt concept]

Keyword's position in hierarchy(ies) :

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