NCIt definition : A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential
antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca
rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule
assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle
and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability
of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile.
Compared to standard liposomal delivery, sphingosomal drug delivery further increases
circulation time of serum drug and enhances drug accumulation at tumor sites, thereby
leading to a further increase in efficacy.;