Preferred Label : Human Thymosin-Fraction 5;
NCIt synonyms : Thymosin Fraction 5;
NCIt definition : A partially purified preparation isolated from the thymus and containing several peptides.
Human Thymosin-Fraction 5 (TF-5) possesses immunopotentiating properties and can correct
many of the immunological deficiencies resulting from the lack of thymosin function
in animal models and in humans. This agent enhances the spontaneous natural killer
activity of normal human large granular lymphocytes; exhibits additive effects with
recombinant IFN-alpha in enhancing natural killer activity in vitro and; enhances
IL2 production, IL2 receptor expression, and IFN-gamma production in mitogen-stimulated
large granular lymphocytes. TF-5 may also modulate the secretion of some hypothalamic
peptides and pituitary hormones, including prolactin and growth hormone. (NCI04);
NSC code : 350391;
Origin ID : C2700;
UMLS CUI : C5441612;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
