Preferred Label : Iodine I 131 Monoclonal Antibody CC49-deltaCH2;
NCIt synonyms : I131 MOAB CC49-deltaCH2; 131I-HuCC49-deltaCH2; 131I-MOAB CC49-deltaCH2;
NCIt definition : A radioimmunoconjugate consisting of the humanized CH2 domain-deleted monoclonal antibody
CC49 and iodine I 131 with antineoplastic activity. Monoclonal antibody CC49-deltaCH2
targets the tumor-associated glycoprotein 72 (TAG-72) that is expressed by a wide
range of human neoplasms including colorectal, gastric, pancreatic, ovarian, endometrial,
breast, non-small cell lung, and prostate cancers. Iodine I 131 monoclonal antibody
CC49-deltaCH2 binds to tumor cells expressing TAG-72, selectively delivering a cytotoxic
dose of beta and gamma radiation.;
Origin ID : C2697;
UMLS CUI : C1134477;
Semantic type(s)
- concept_is_in_subset
- has_target
