NCIt definition : A disorder characterized by the inability of the liver to metabolize chemicals in
the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms
include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma
levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase.;
Alternative definition : CTCAE: A disorder characterized by the inability of the liver to metabolize chemicals
in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin,
lactic dehydrogenase, and alkaline phosphatase.; FDA: Sustained, and severe damage to the liver with significant loss of function.;