NCIt synonyms : Minor Bupleurum Formula; Xiao Chai Hu Tang; Keisho-To;
NCIt related terms : Xiao-Chai-Hu-Tang;
NCIt definition : A botanical formulation with potential chemopreventive activities. Sho-Saiko-to, an
herbal mixture, contains seven herbal extracts whose mechanism of action if not fully
understood. There is evidence of antiproliferative effects against hepatocellular
carcinoma in vitro. Other effects of this agent described in animal models include
the prevention of liver injury and hepatocyte-regenerating activity. Antitumor effects
associated with this herbal product may include induction of apoptosis, cell cycle
arrest at the G0/G1 phase, and activation of an immune response, characterized by
the release of cytokines as well as activation of effector cells, such as macrophages
and natural killer cells.;
Alternative definition : NCI-GLOSS: A Japanese formulation of seven Chinese herbs that is being studied as
a treatment for cancer.;