Recombinant Fowlpox GM-CSF Vaccine Adjuvant

Preferred Label : Recombinant Fowlpox GM-CSF Vaccine Adjuvant;

NCIt synonyms : Fowlpox-Sargramostim; rF-Sargramostim; rF-GM-CSF;

NCIt definition : A cancer vaccine adjuvant consisting of a recombinant fowlpox virus encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF binds to specific cell surface receptors on various immuno-hematopoietic cell types, enhancing their proliferation and differentiation and stimulating macrophage and dendritic cell functions in antigen presentation and antitumor cell-mediated immunity. Administration of recombinant fowlpox GM-CSF vaccine adjuvant may induce an immune response against tumor cells. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.;

NSC code : 707299;

Details

Origin ID

C2686;

UMLS CUI

C1134686;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Granulocyte [NCIt concept]
- Macrophage [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cytokine Receptor Activation [NCIt concept]
- Immunopotentiation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- GM-CSF Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox-CEA-TRICOM Vaccine/Fowlpox-Sargramostim [NCIt concept]
- Fowlpox-PSA-TRICOM Vaccine/Fowlpox-Sargramostim Vaccine/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine [NCIt concept]
- Fowlpox-Sargramostim Vaccine/Fowlpox-TRICOM Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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