" /> Ziv-Aflibercept - CISMeF





Preferred Label : Ziv-Aflibercept;

NCIt synonyms : Vascular Endothelial Growth Factor Trap; VEGF Trap R1R2; AVE0005; Aflibercept beta;

NCIt related terms : VEGF-Trap; aflibercept; VEGF Trap;

NCIt definition : A recombinant protein comprised of epitopes of the extracellular domains of human vascular endothelial growth factor receptors (VEGFR) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. Vascular endothelial growth factor trap blocks the action of vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.;

UNII : 15C2VL427D;

CAS number : 862111-32-8;

Drug name : Eylea; Zaltrap;

NSC code : 724770;

Codes from synonyms : CDR0000597249; CDR0000256544; 50707; CDR0000597250; 549;

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29/05/2025


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