NA17.A2 Peptide Vaccine

Preferred Label : NA17.A2 Peptide Vaccine;

NCIt synonyms : NA17.A2; NA17 A2 Antigen;

NCIt definition : A peptide cancer vaccine comprised of human leukocyte antigen HLA-A2-restricted peptide derived from a metastatic melanoma cell line of patient NA17, with potential immunomodulating and antineoplastic activity. NA17.A2 peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumors that express this antigen, which may result in a reduction in tumor size. This NA17 specific antigen, encoded by an intron sequence of N-acetylglucosaminyltransferase V (GnT-V) gene, is expressed in about 50% of melanomas.;

NCI Metathesaurus CUI : CL423775;

Details

Origin ID

C2680;

UMLS CUI

C2987456;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- gp100 Antigen/Melan-A/Na17.A2 Antigen/Tyrosinase Peptide [NCIt concept]

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