Colchicine-Site Binding Agent ABT-751

Preferred Label : Colchicine-Site Binding Agent ABT-751;

NCIt synonyms : N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide;

NCIt related terms : ABT-751;

NCIt definition : An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides.;

UNII : WDT5V5OB9F;

InChIKey : URCVCIZFVQDVPM-UHFFFAOYSA-N;

CAS number : 141430-65-1;

Molecule name : ABT-751; E-7010; E 7010;

Codes from synonyms : 50573; CDR0000256536;

Details

Origin ID

C2679;

UMLS CUI

C4764397;

False automatic mappings
- E 7010 [MeSH Supplementary Concept]
- N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ABT751 [MeSH concept]
- ABT751 [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Beta Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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