Preferred Label : Oncolytic HSV-1 G207;
NCIt related terms : G207;
NCIt definition : A neuroattenuated, replication-competent, recombinant herpes simplex virus-1 (HSV-1)
with potential oncolytic activity. Upon intracerebral administration, oncolytic HSV-1
G207 preferentially replicates within glioma cells, which may elicit tumor-specific
systemic immune and cytotoxic T lymphocyte (CTL) responses in addition to direct cytopathic
effects. Derived from wild-type HSV-1 strain F, this agent has been neuroattenuated
by deletions in both copies of the gamma34.5 gene, the major determinant of HSV neurovirulence.
In addition, the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large
subunit infected cell protein 6 (ICP6), has been inactivated through the insertion
of the Escherichia coli lacZ gene. By inactivating UL39, viral ribonucleotide reductase
activity is disrupted, resulting in the inhibition of nucleotide metabolism and viral
DNA synthesis in nondividing cells but not in dividing cells.;
Molecule name : G207;
Codes from synonyms : 34886;
Origin ID : C2676;
UMLS CUI : C1134718;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
