NCIt definition : A localized or systemic chronic and progressive autoimmune disorder characterized
by thickening of the skin and the connective tissues. Localized scleroderma affects
only the skin. Systemic scleroderma affects internal organs, including the heart,
lungs, gastrointestinal tract, and kidneys.;
Alternative definition : NICHD: A chronic and progressive autoimmune disorder characterized by thickening of
the skin and the connective tissues.; NCI-GLOSS: A chronic disorder marked by hardening and thickening of the skin. Scleroderma
can be localized or it can affect the entire body (systemic).;