Preferred Label : Epothilone D;
NCIt synonyms : Desoxyepothilone B; 12,13-Deoxyepothilone B; (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione;
NCIt related terms : KOS-862;
NCIt definition : A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum.
Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly
of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and
cell motility. (NCI04);
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of mitotic
inhibitor and epothilone.;
UNII : T0358E0YUF;
CAS number : 189453-10-9;
Molecule name : KOS 862;
Chemical formula : C27H41NO5S;
NSC code : 703147;
Codes from synonyms : 50535; CDR0000367445; CDR0000367444; NSC0703147;
Origin ID : C2672;
UMLS CUI : C0962559;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
