Endothelin Receptor Type A Antagonist YM598

Preferred Label : Endothelin Receptor Type A Antagonist YM598;

NCIt synonyms : Potassium (E)-N-[6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylenthene Sulfonamidate;

NCIt related terms : NEBENTAN POTASSIUM; YM598;

NCIt definition : An orally active synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for advanced prostate cancer and for pain caused by prostate cancer that has spread to the bone. It belongs to the family of drugs called endothelin ETA receptor antagonists.;

UNII : OK6K3MDZ98;

CAS number : 342005-82-7;

Molecule name : YM598;

Codes from synonyms : CDR0000302471;

PubMed : 16843458;

Details

Origin ID

C26678;

UMLS CUI

C1175067;

Currated CISMeF NLP mapping
- YM598 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- YM598 [MeSH concept]
Validated automatic mappings to NTBT
- N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Mitoxantrone/Prednisone/YM598 [NCIt concept]

Keyword's position in hierarchy(ies) :

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