Preferred Label : Transferrin-CRM107;
NCIt definition : A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated
to a diphtheria toxin that contains a point mutation (CRM107). After binding to the
transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized,
where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting
protein synthesis through ADP-ribosylation of elongation factor. (NCI04);
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of brain tumors. Transferrin-CRM107
is made by linking a diphtheria toxin to transferrin, a protein that binds to fast
growing cells, such as tumor cells. The diphtheria toxin then kills the tumor cells.
Transferrin-CRM107 is a type of immunotoxin.;
Molecule name : HN-66000;
Codes from synonyms : CDR0000390295;
Origin ID : C26676;
UMLS CUI : C0912205;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
