Soblidotin - CISMeF

Preferred Label : Soblidotin;

NCIt synonyms : Auristatin PE; N(2)-(N,N-Dimethyl-valyl)-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenylethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-valinamide;

NCIt related terms : TZT-1027;

NCIt definition : A dolastatin-10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of tubulin inhibitor.;

UNII : DQC51A0WQH;

InChIKey : DZMVCVHATYROOS-ZBFGKEHZSA-N;

CAS number : 149606-27-9;

Molecule name : TZT-1027;

Chemical formula : C39H67N5O6;

Codes from synonyms : CDR0000321390; CDR0000321388;

Details

Origin ID

C26672;

UMLS CUI

C1328702;

Automatic exact mappings (from CISMeF team)
- auristatin PE [MeSH concept]
Currated CISMeF NLP mapping
- soblidotin [MeSH concept]
- soblidotin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- soblidotin [MeSH Supplementary Concept]
- soblidotin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Gemcitabine/Soblidotin [NCIt concept]

Keyword's position in hierarchy(ies) :

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