Preferred Label : Seocalcitol;
NCIt synonyms : (1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol; 1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene;
NCIt definition : A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to
and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal
vitamin D responsive tissues, but also overexpressed in certain cancers including
hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor,
this agent induces cancer cell differentiation, inhibits cancer cell growth and induces
apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent
of vitamin D receptor activation through mechanisms that are not fully elucidated.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called vitamin D analogs.;
UNII : Q0OZ0D9223;
InChIKey : LVLLALCJVJNGQQ-SEODYNFXSA-N;
CAS number : 134404-52-7;
Molecule name : EB1089;
Chemical formula : C30H46O3;
Codes from synonyms : 20096; CDR0000306515;
Origin ID : C26669;
UMLS CUI : C0905598;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
