" /> Edotecarin - CISMeF





Preferred Label : Edotecarin;

NCIt synonyms : 6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)-5H-indolo[2,3-a]-pyrrolol[3,4-c]-carbazole-5,7(6H)-dione;

NCIt related terms : J-107088;

NCIt definition : A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor.;

UNII : 1V8X590XDP;

InChIKey : QMVPQBFHUJZJCS-NTKFZFFISA-N;

CAS number : 174402-32-5;

Molecule name : J-107088;

Chemical formula : C29H28N4O11;

Codes from synonyms : CDR0000045074; CDR0000334457;

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08/05/2025


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