HER2 Inhibitor CP-724,714

Preferred Label : HER2 Inhibitor CP-724,714;

NCIt synonyms : CP-724 714;

NCIt related terms : CP-724714; CP-724,714;

NCIt definition : An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called ErbB receptor tyrosine kinase inhibitors.;

UNII : I05QZ0S4V3;

CAS number : 383432-38-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 383432-38-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CP-724,714; CP-724-714; CP 724714;

Codes from synonyms : CDR0000305989;

Details

Origin ID

C26648;

UMLS CUI

C1327906;

Automatic exact mappings (from CISMeF team)
- 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- CP 724714 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CP 724714 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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