Preferred Label : Monoclonal Antibody CAL;
NCIt definition : A humanized monoclonal antibody directed against parathyroid hormone-related protein
(PTH-rP). As a poly-hormone with diverse biological roles, PTH-rP is expressed by
normal tissues, acting in local tissue environments in a variety of ways; it is commonly
overexpressed by breast, prostate, and other cancers, acting systemically by promoting
bone resorption, inhibiting calcium excretion from the kidney, inducing hypercalcemia,
and possibly playing a role in the formation of bony metastases. By blocking the effects
of PTH-rP on calcium metabolism, monoclonal antibody CAL may inhibit cancer-related
hypercalcemia. (NCI04);
Origin ID : C2659;
UMLS CUI : C1135160;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
