" /> DHA-Paclitaxel - CISMeF





Preferred Label : DHA-Paclitaxel;

NCIt synonyms : Docosahexaenoic Acid-Paclitaxel conjugate; TXP;

NCIt related terms : PACLITAXEL DOCOSAHEXAENOIC ACID;

NCIt definition : A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer. (NCI04);

Alternative definition : NCI-GLOSS: A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.;

UNII : OJE5810C4F;

CAS number : 73-67-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 73-67-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Taxoprexin;

NSC code : 28247;

Codes from synonyms : CDR0000045043;

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15/05/2024


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