" /> Melanoma-Associated Antigen D1 - CISMeF





Preferred Label : Melanoma-Associated Antigen D1;

NCIt synonyms : MAGE Tumor Antigen CCF; NRAGE Protein; Neurotrophin Receptor-Interacting MAGE Homolog; Urotrophin Receptor-Interacting MAGE Homolog Protein; PRO2292; MAGED1; MAGE-D1 Antigen;

NCIt definition : Melanoma-associated antigen D1 (778 aa, 86 kDa) is encoded by the human MAGED1 gene. This protein is involved in apoptosis.;

NCIt note : Encoded by MAGED1 Gene (MAGE Family), ubiquitous 778-amino acid 86-kD cytoplasmic NRAGE Protein contains a 200-amino acid MAGE homology domain. NRAGE appears to shift from cytoplasm to plasma membrane upon NGF stimulation to interact with p75NTR. NRAGE antagonizes p75NTR association with TRKA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. NRAGE may regulate the function of DLX family members. (from LocusLink, Swiss-Prot, OMIM, and NCI);

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31/07/2025


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