Preferred Label : Methyl-5-Aminolevulinate Hydrochloride Cream;
NCIt synonyms : Methyl Aminolevulinate Hydrochloride Cream;
NCIt related terms : methyl-5-aminolevulinate;
NCIt definition : A topical cream formulation containing the hydrochloride salt of methyl-5-aminolevulinate,
a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity.
Upon topical administration, methyl-5-aminolevulinate in the cream is selectively
absorbed by tumor cells where it is converted to the photosensitizer protoporphyrin
IX (PpIX). Upon photoirradiation, PpIX is activated and transfers energy to oxygen,
generating singlet oxygen and superoxide and hydroxyl radicals, which may result in
free-radical-mediated DNA damage and cell death.;
Alternative definition : NCI-GLOSS: A drug used in photodynamic therapy; it is absorbed by tumor cells and,
when exposed to light, becomes active and kills the cancer cells.;
Drug name : Metvix; Metvixia;
Codes from synonyms : CDR0000045042;
Origin ID : C2647;
UMLS CUI : C2713112;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
