Monoclonal Antibody GD2 Anti-Idiotype Vaccine

Preferred Label : Monoclonal Antibody GD2 Anti-Idiotype Vaccine;

NCIt definition : A class of vaccines that consist of anti-idiotype monoclonal antibodies against the tumor-associated antigen disialoganglioside GD2 with potential antineoplastic activity. Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC). GD2 is overexpressed in melanoma, neuroblastoma, soft tissue sarcoma, and small cell carcinoma of the lung. (NCI04);

Details

Origin ID

C26450;

UMLS CUI

C1328690;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Etoposide/Monoclonal Antibody 11D10 Anti-Idiotype Vaccine/Monoclonal Antibody GD2 Anti-Idiotype Vaccine [NCIt concept]
- Monoclonal Antibody 11D10 Anti-Idiotype Vaccine/Monoclonal Antibody GD2 Anti-Idiotype Vaccine [NCIt concept]

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