Preferred Label : Doxorubicin-Magnetic Targeted Carrier Complex;
NCIt synonyms : DOX-MTC; MTC-DOX;
NCIt definition : A formulation of the anthracycline antibiotic doxorubicin in which doxorubicin is
bound to microscopic beads of activated carbon and iron as a magnetic-targeted carrier
(MTC). Doxorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA
replication and ultimately inhibits protein synthesis. This agent also generates oxygen
free radicals, resulting in cytotoxic lipid peroxidation of cell membrane lipids.
Guided by the placement of a magnet on the body surface overlying a tumor site, the
doxorubicin-MTC complex delivers doxorubicin directly to the tumor site, thereby targeting
and prolonging the duration of doxorubicin-mediated cytotoxicity to the tumor bed
while minimizing systemic toxicity.;
Origin ID : C2644;
UMLS CUI : C1134452;
Semantic type(s)
- concept_is_in_subset
