Preferred Label : Taurolidine;
NCIt synonyms : Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane;
NCIt definition : A synthetic broad-spectrum antimicrobial with antibacterial, antifungal, anticoagulant,
and potential antiangiogenic activities. Taurolidine, derived from the amino acid
taurine, binds to and neutralizes bacterial exotoxins and endotoxins, or lipopolysaccharides
(LPS). Taurolidine binding to LPS prevents bacterial adherence to host epithelial
cells, thereby prevents bacterial invasion of uninfected host cells. Although the
mechanism underlying its antineoplastic activity has not been fully elucidated, it
may be related to this agent's anti-adherence property. In addition, taurolidine also
promotes apoptosis by inducing various apoptotic factors and suppresses the production
of vascular endothelial growth factor (VEGF), a protein that plays an important role
in angiogenesis.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called anti-infectives.;
UNII : 8OBZ1M4V3V;
InChIKey : AJKIRUJIDFJUKJ-UHFFFAOYSA-N;
CAS number : 19388-87-5;
Drug name : Taurolin;
Chemical formula : C7H16N4O4S2;
Codes from synonyms : CDR0000045033;
Origin ID : C2639;
UMLS CUI : C0144567;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
