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Preferred Label : HPPH;

NCIt synonyms : 2-(1-Hexyloxyethyl)-2-Devinyl Pyropheophorbide-a; 2-[1-Hexyloxyethyl]-2-devinyl Pyropheophorbide-alpha;

NCIt related terms : 2-(1-HEXYLOXYETHYL)-2-DEVINYLPYROPHEOPHORBIDE A;

NCIt definition : A lipophilic, second-generation, chlorin-based photosensitizer. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells. When laser light is applied, a photodynamic reaction between HPPH and oxygen occurs, resulting in the production of cytotoxic free radicals and singlet oxygen and free radical-mediated cell death. Compared to the first-generation photosensitizer porfimer sodium, HPPH shows improved pharmacokinetic properties and causes only mild skin photosensitivity which declines rapidly within a few days after administration.;

Alternative definition : NCI-GLOSS: A drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.;

UNII : DOB7Y3RSX0;

InChIKey : PVXGCBZIVFCMJK-NMWXTPPCSA-N;

CAS number : 149402-51-7;

Drug name : Photochlor;

Codes from synonyms : CDR0000045031;

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08/05/2025


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