Preferred Label : Pelitrexol;
NCIt synonyms : (2S)-2-[[[5-[2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methylthiophen-2-yl]carbonyl]amino]pentanedioic
Acid; (2S)-2-(((5-(2-((6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido(2,3-d)pyrimidin-6-yl)ethyl)-4-methylthiophen-2-yl)carbonyl)amino)pentanedioic
Acid;
NCIt related terms : AG2037;
NCIt definition : A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity
of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent
enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme
inhibition reduces the purine nucleotides pool required for DNA replication and RNA
transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately
inhibits tumor cell proliferation;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.;
UNII : DHT6E8M4KP;
InChIKey : QXOPTIPQEVJERB-JQWIXIFHSA-N;
CAS number : 446022-33-9;
Molecule name : AG2037;
Chemical formula : C20H25N5O6S;
Codes from synonyms : CDR0000045027;
Origin ID : C2633;
UMLS CUI : C1871457;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
