Preferred Label : Naxtarubicin;
NCIt synonyms : 5,12-naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-l-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-,
(7S-cis)-; 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin;
NCIt related terms : annamycin;
NCIt definition : A lipophilic, anthracycline antineoplastic antibiotic.Naxtarubicin intercalates into
DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as
well as inhibiting RNA and protein synthesis. This agent appears to not be a substrate
for the p-glycoprotein associated multidrug-resistance (MDR) transporter; therefore,
overcoming the resistance pattern seen with other anthracycline compounds.;
UNII : SNU299M83Q;
InChIKey : CIDNKDMVSINJCG-GKXONYSUSA-N;
CAS number : 92689-49-1;
Chemical formula : C26H25IO11;
Codes from synonyms : CDR0000045025;
Origin ID : C2632;
UMLS CUI : C0214529;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
