NCIt related terms : PNU-93914; LipoTaxen; LEP-ETU; liposomal paclitaxel;
NCIt definition : A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from
the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds
to tubulin and interferes with the assembly/disassembly dynamics of microtubules,
thereby resulting in the inhibition of cell division. This agent also induces apoptosis
via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel
liposome formulation potentially enhances delivery of higher doses of paclitaxel to
the target tissues and exhibits lower systemic toxicity.;
Alternative definition : NCI-GLOSS: A form of the anticancer drug paclitaxel that is contained in very tiny,
fat-like particles. It may have fewer side effects and work better than paclitaxel.
It is being studied in the treatment of several types of cancer. Paclitaxel liposome
blocks the ability of cells to divide and may kill cancer cells. It is a type of mitotic
inhibitor and a type of antimicrotubule agent.;
Codes from synonyms : CDR0000423263; CDR0000423261; CDR0000046527; CDR0000663505; CDR0000663507;
Semantic type(s)