Preferred Label : Oncolytic HSV-1 NV1020;
NCIt related terms : NV1020;
NCIt definition : A genetically engineered oncolytic virus with potential antineoplastic property. NV1020
is constructed from the herpes simplex virus 1 (HSV-1) by the deletion of a single
copy of the gamma (1)34.5 gene and the substitution of the UL23 region of the thymidine
kinase (tk) gene with a DNA fragment from HSV-2, thereby resulting in a replication-competent,
attenuated virus. This modified virus preferentially transfects rapidly dividing cells,
which causes cell lysis in tumor cells. NV1020 has shown reduced virulence against
normal tissues and a decreased neurovirulence in comparison with some other modified
HSV strains.;
Molecule name : NV1020;
Origin ID : C2623;
UMLS CUI : C0935802;
Semantic type(s)
- concept_is_in_subset
