Beta-Defensin 1

Preferred Label : Beta-Defensin 1;

NCIt synonyms : DEFB1; BD-1; Beta Defensin 1; hBD-1; Defensin, Beta 1; Beta Defensin-1 Protein;

NCIt definition : Beta-defensin 1 (68 aa, 7 kDa) is encoded by the human DEFB1 gene. This protein is involved in chemotaxis and has bactericidal activity.;

NCIt note : Encoded by human DEFB1 Gene (Beta-Defensin Family), Beta-Defensin 1 Protein prepropeptide contains a 68-amino acid secreted antimicrobial plasma peptide implicated in cystic fibrosis pathogenesis. Multiple plasma forms are bound to carrier macromolecules. Highest DEFB1 concentrations occur in kidney and female reproductive tract epithelia. DEFB1 may act in innate immunity. Mammalian alpha- and beta-defensins comprise 3.5- to 5-kD cysteine- and arginine-rich neutrophilic microbicidal and cytotoxic peptides. (from LocusLink, Swiss-Prot, OMIM, and NCI);

Details

Origin ID

C26216;

UMLS CUI

C0625647;

False automatic mappings
- hBD-1(Ser35), human [MeSH concept]
OMIM relation
- Defensin, beta, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DEFB1 protein, human [MeSH Supplementary Concept]
- DEFB1 protein, human [MeSH concept]
gene_encodes_gene_product
- DEFB1 Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Kidney [NCIt concept]
gene_product_has_associated_anatomy
- Plasma [NCIt concept]
gene_product_has_biochemical_function
- Immunoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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