Gavilimomab - CISMeF

Preferred Label : Gavilimomab;

NCIt synonyms : Monoclonal Antibody ABX-CBL; anti-CD147 Monoclonal Antibody ABX-CBL;

NCIt definition : A murine IgM monoclonal antibody (MoAb) developed for the potential treatment of graft versus host disease (GvHD). MoAb ABX-CBL recognizes human CD147 antigen, weakly expressed on human leukocytes and up-regulated on activated lymphocytes. This MoAb is capable of neutralizing inflammatory reactions via a complement-dependent cytotoxic mechanism. However, MoAb ABX-CBL does not offer an improvement over antithymocyte globulin in the treatment of acute steroid resistant GVHD.;

UNII : TCR92293RC;

CAS number : 244096-20-6;

PubMed : 17110457;

Details

Origin ID

C2621;

UMLS CUI

C0935795;

Currated CISMeF NLP mapping
- Gavilimomab [SMS substance]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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