EGFR Antisense DNA

Preferred Label : EGFR Antisense DNA;

NCIt definition : A synthetic sequence of DNA constructed in the antisense orientation to a sequence of DNA in epidermal growth factor receptor (EGFR), a member of the erbB gene family. EGFR antisense DNA suppresses the expression of EGFR by tumor cells, thereby inhibiting tumor cell proliferation and decreasing tumor growth. This agent also appears to reduce the invasiveness of certain breast cancer cells. Members of the erbB gene family are overexpressed in many cancers and play roles in carcinogenesis and the regulation of cell proliferation. (NCI04);

Details

Origin ID

C2617;

UMLS CUI

C0935778;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- DC-Chol Liposomes/EGFR Antisense DNA [NCIt concept]
- EGFR Antisense DNA/Keyhole Limpet Hemocyanin [NCIt concept]
- EGFR Antisense DNA/Sargramostim [NCIt concept]

Keyword's position in hierarchy(ies) :

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