Preferred Label : Edotreotide;
NCIt synonyms : DOTA-Tyr3-octreotide; DOTATOC; (DOTA(0)-Phe(1)-Tyr(3))octreotide; L-Cysteinamide, N-((4,7,10-tris(carboxymetnyl)-1,4,7,10-tetraazacyclodec-1-yl)acetyl)-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-,
cyclic(2-7)-disulfide;
NCIt definition : A chelated octreotide derivative with somatostatin activity. Edotreotide is produced
by substituting tyrosine for phenylalanine at the 3 position of octreotide and chelated
via dodecanetetraacetic acid (DOTA). Like octreotide, this edotreotide binds to somatostatin
receptors (SSTRs), especially type 2, present on the cell membrane of many types of
neuroendocrine tumors. When labeled with nuclides, edotreotide conjugates could result
in tissue specific cytotoxicity.;
UNII : U194AS08HZ;
InChIKey : RZHKDBRREKOZEW-AAXZNHDCSA-N;
CAS number : 204318-14-9;
Molecule name : SMT-487;
Chemical formula : C65H92N14O18S2;
PubMed : 16917205;
Origin ID : C2616;
UMLS CUI : C0539568;
Semantic type(s)
- concept_is_in_subset
