Preferred Label : INS316;
NCIt synonyms : UTP Solution; Uridine 5-Triphosphate Solution;
NCIt related terms : URIDINE 5'-TRIPHOSPHATE;
NCIt definition : A short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic
aid for lung cancer. INS316 appears to improve sputum expectoration mediated through
the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells
and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction
that leads to chloride ion secretion, thereby resulting in mucociliary clearance of
airway.;
Alternative definition : NCI-GLOSS: A substance being studied in the diagnosis of lung diseases, including
lung cancer. It helps bring up a sample of mucus from deep in the lungs and improves
the quality of the sample for testing. It is a type of nucleoside triphosphate.;
UNII : UT0S826Z60;
InChIKey : PGAVKCOVUIYSFO-XVFCMESISA-N;
CAS number : 63-39-8;
Codes from synonyms : CDR0000390287;
Origin ID : C2613;
UMLS CUI : C0935963;
Semantic type(s)
- concept_is_in_subset
