Preferred Label : Monoclonal Antibody Mono-dgA-RFB4;
NCIt synonyms : MONO dgA RFB4;
NCIt definition : An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated
ricin toxin A-chain (dgA), originated from castor beans. MoAb RFB4 recognizes CD22
antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent
of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent
protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate
to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin
to CD22-positive malignant cells.;
Origin ID : C2611;
UMLS CUI : C0935906;
Semantic type(s)
- concept_is_in_subset
