Preferred Label : Von Willebrand Factor A Domain;
NCIt definition : The type A domain (vWF) of the von Willebrand factor, a large multimeric glycoprotein
found in blood plasma, is the prototype for a protein superfamily. Von Willebrand
Factor A Domain is found in various plasma proteins and other extracellular proteins.
Although the majority of VWA-containing proteins are extracellular, the most ancient
ones present in all eukaryotes are all intracellular proteins involved in functions
such as transcription, DNA repair, ribosomal and membrane transport and the proteasome.
A common feature appears to be involvement in multiprotein complexes. Proteins that
incorporate vWF domains participate in numerous biological events (e.g. cell adhesion,
migration, homing, pattern formation, and signal transduction), involving interaction
with a large array of ligands. A number of human diseases arise from mutations in
VWA domains. (From Interpro IPR002035);
Origin ID : C26043;
UMLS CUI : C1520063;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
