Preferred Label : Carmustine in Ethanol;
NCIt definition : A formulation containing carmustine dissolved in ethanol for intra-tumoral administration
that allows carmustine to enter both aqueous and lipid compartments of the target
tissue. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA
during all phases of the cell cycle, resulting in disruption of DNA function, cell
cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA
repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic
and crosses the blood-brain barrier readily.;
Molecule name : DTI-015;
Origin ID : C2602;
UMLS CUI : C0935694;
Semantic type(s)
- concept_is_in_subset
