Preferred Label : Membrane-Associated Guanylate Kinase Family Gene;
NCIt synonyms : MAGUK Family Gene;
NCIt definition : Membrane-Associated Guanylate Kinase Family Genes encode MAGUK (Membrane-Associated
GUanylate Kinase homolog) proteins containing DHR, SH3, and C-terminal GK-like domains.
MAGUKs include Drosophila lethal(1)discs large-1 tumor suppressor protein (dlg1);
mammalian Zo-1 tight junction protein; mammalian synaptic proteins that seem to interact
with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93,
SAP97/DLG1 and SAP102); 55 kD erythrocyte membrane protein (p55); C. elegans lin-2
protein; rat CASK protein; and human DLG2 and DLG3 proteins. An N-terminal ATP-binding
site (P-loop) of Guanylate Kinase is not conserved in the MAGUK GK-like domain; MAGUKs
do retain residues known in GK to bind GMP. (NCI);
NCIt note : Members of membrane-associated guanylate kinase (MAGUK) gene family encode a guanylate
kinase (GUK) domain with a catalytically inactive P-loop, which cannot bind ATP. It
is thought that MAGUKs use their GUK domain to interact with cytoskeletal proteins
and signaling molecules. (HGNC);
Origin ID : C25981;
UMLS CUI : C1334692;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
