NCIt definition : Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane
Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which
respond to various microbial components and mediate pathogen recognition and activation
of innate immunity to microbial agents. Sharing structural and functional similarities,
highly conserved TLRs recognize pathogen-associated molecular patterns expressed on
infectious agents and mediate cytokine production necessary for effective immunity.
TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine
production and secretion, and inflammatory response. (NCI);
Semantic type(s)