St. John's Wort

Preferred Label : St. John's Wort;

NCIt synonyms : Hypericum Perforatum Extract; St John's Wort;

NCIt related terms : hypericum perforatum;

NCIt definition : An herbal extract prepared from the plant Hypericum perforatum (St. John's wort) with photodynamic, antineoplastic, and antidepressant activities. Hypericin, one of the active compounds found in Hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs.;

Alternative definition : NCI-GLOSS: An herbal product sold as an over-the-counter treatment for depression. It is being studied for its ability to lessen certain side effects of cancer treatment.;

UNII : UFH8805FKA;

CAS number : 84082-80-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 84082-80-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Codes from synonyms : CDR0000044462; CDR0000044957;

Details

Origin ID

C2589;

UMLS CUI

C0813171;

Currated CISMeF NLP mapping
- Hypericum perforatum extract (substance) [SNOMED CT concept]
- hypericum extract LI 160 [MeSH concept]
- hypericum extract LI 160 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hyperici herba [ATC Code]
- Hypericum perforatum extract (substance) [SNOMED CT concept]
- Saint John's wort extract [MeSH Supplementary Concept]
- St. John's wort [LOINC component]
Validated automatic mappings to NTBT
- St. John's wort [LOINC component]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Docetaxel/Hypericum perforatum [NCIt concept]

Keyword's position in hierarchy(ies) :

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