Preferred Label : Progenipoietin;
NCIt synonyms : Progenipoetin; Flt-3 ligand/G-CSF fusion protein; Filgrastim-Fetal Liver Tyrosine Kinase-3 Fusion Protein; ProGP;
NCIt definition : A recombinant, chimeric, dual-receptor agonist fusion protein with immunohematopoietic
activity. Progenipoietin (ProGP) consists of portions of the ligands for granulocyte
colony-stimulating factor (G-CSF) and human fetal liver tyrosine kinase-3 (FLT3);
variants progenipoietin-1, 2 and 3 differ in the orientation of the two receptor agonists.
ProGP binds simultaneously to G-CSF and FLT3 receptors with receptor affinities approximately
two- to three-fold higher than the respective native ligands. When administered in
vivo, this agent may augment the number of circulating granulocytes and dendritic
cells (DCs). ProGP may promote the proliferation of and prevent apoptosis in several
human hematopoietic cell lineages, exhibiting the additive activities of a combination
of C-GSF and FLT3.;
Molecule name : SD-9427;
NSC code : 715819;
Origin ID : C2587;
UMLS CUI : C0879506;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
