Indisulam - CISMeF

Preferred Label : Indisulam;

NCIt synonyms : N-(3-Chloro-7-indoyl)-1,4-Benzenedisulfonamide;

NCIt related terms : E7070;

NCIt definition : A novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA), especially isoforms IX and XII that are involved in aqueous humor production and are highly overexpressed in some types of cancers. Inhibition of CA IX and XII results in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance to weakly basic antineoplastic agents.;

Alternative definition : NCI-GLOSS: A drug that belongs to the family of drugs called sulfonamides. It is being studied for its ability to treat cancer.;

UNII : WJ98J3NM90;

InChIKey : SETFNECMODOHTO-UHFFFAOYSA-N;

CAS number : 165668-41-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 165668-41-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : E7070;

Chemical formula : C14H12ClN3O4S2;

Codes from synonyms : CDR0000046718;

Details

Origin ID

C25797;

UMLS CUI

C1099211;

Currated CISMeF NLP mapping
- N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide [MeSH Supplementary Concept]
- N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide [MeSH Supplementary Concept]
- N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carbonic Anhydrase 9 [NCIt concept]
is_component_of_chemotherapy_regimen
- E7070/Irinotecan [NCIt concept]

Keyword's position in hierarchy(ies) :

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