NCIt definition : A novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits
cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually
over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest
of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor
cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA),
especially isoforms IX and XII that are involved in aqueous humor production and are
highly overexpressed in some types of cancers. Inhibition of CA IX and XII results
in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance
to weakly basic antineoplastic agents.;
Alternative definition : NCI-GLOSS: A drug that belongs to the family of drugs called sulfonamides. It is being
studied for its ability to treat cancer.;