NCIt definition : An antimetabolite and a chlorine derivative of the intracellular secondary messenger,
cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity.
Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and
subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue
and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes
endogenous ATP pool that is essential for many biological reactions in intracellular
energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular
proliferation, and induces apoptosis.;
Alternative definition : NCI-GLOSS: A substance that is being studied as an anticancer drug. It is an analogue
of a substance that occurs naturally in the body (cyclic adenosine monophosphate).;
UNII : BQ94Z7E5OR;
InChIKey : CLLFEJLEDNXZNR-UUOKFMHZSA-N;
CAS number : 41941-56-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 41941-56-4
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Currated CISMeF NLP mapping