NCIt definition : An antimetabolite and a chlorine derivative of the intracellular secondary messenger,
cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity.
Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and
subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue
and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes
endogenous ATP pool that is essential for many biological reactions in intracellular
energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular
proliferation, and induces apoptosis.;
Alternative definition : NCI-GLOSS: A substance that is being studied as an anticancer drug. It is an analogue
of a substance that occurs naturally in the body (cyclic adenosine monophosphate).;
Currated CISMeF NLP mapping