" /> T-Cell Receptor Excision Circle - CISMeF





Preferred Label : T-Cell Receptor Excision Circle;

NCIt synonyms : TREC; T-Cell Receptor-Rearrangement Excision DNA Circle; T-Cell Receptor-Rearrangement Excision DNA Circles;

NCIt definition : The reciprocal product of T-cell receptor (TCR) gene rearrangement. Following TCR gene rearrangement the T-cell receptor excision circle (TREC) is maintained in the cell as a non-replicating episome. With each cell division the TREC is segregated to a single daughter cell and becomes diluted in the population. Recent TCR rearrangement can be detected by a spike in the number of TREC and can be used to quantify thymic T-cell output.;

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07/05/2025


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