Salmonella VNP20009

Preferred Label : Salmonella VNP20009;

NCIt synonyms : Live, Attenuated Salmonella Typhimurium; Auxotrophic Lipid A S. Typhimurium mutant;

NCIt related terms : VNP20009;

NCIt definition : A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types, inhibiting the growth of primary and metastatic tumors. This agent may be genetically engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated antigen-specific antibodies, such as CEA-specific antibodies, which may improve its tumor targeting and therapeutic potential.;

Alternative definition : NCI-GLOSS: A genetically modified Salmonella bacterium that is injected into the tumor. It is being studied for its ability to shrink solid tumors.;

Molecule name : VNP 20009;

Codes from synonyms : CDR0000044858;

Details

Origin ID

C2556;

UMLS CUI

C0879622;

Automatic exact mappings (from CISMeF team)
- VNP 20009 [MeSH Supplementary Concept]
Semantic type(s)
- Bacterium [UMLS semantic type]
UMLS correspondences (same concept)
- VNP 20009 [MeSH Supplementary Concept]
- VNP 20009 [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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