NCIt synonyms : Live, Attenuated Salmonella Typhimurium; Auxotrophic Lipid A S. Typhimurium mutant;
NCIt related terms : VNP20009;
NCIt definition : A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion
of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella
VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types,
inhibiting the growth of primary and metastatic tumors. This agent may be genetically
engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated
antigen-specific antibodies, such as CEA-specific antibodies, which may improve its
tumor targeting and therapeutic potential.;
Alternative definition : NCI-GLOSS: A genetically modified Salmonella bacterium that is injected into the tumor.
It is being studied for its ability to shrink solid tumors.;